![]() ![]() We have classified these compounds into groups exhibiting shared pharmacological activities and discussed their corresponding biological targets focusing mainly on the most potent therapeutic compounds.Īzaborines Benzoxaboroles Boron Containing Heterocycles Boron containing Drugs Diazaborines Oxadiazaboroles Oxazaborolidines Oxazoborolidine-ones Pharmacological agents.Ĭopyright © 2022 Elsevier Ltd. The present perspective is intended to review the pharmacological applications of boron-based heterocycles that have been published. Boron-based heterocycles have an incredible potential in the ongoing quest for new therapeutic agents owing to their plethora of biological activities and useful pharmacokinetic profiles. They serve as extremely strong bases, as they are very. 1 NHC boryl anions have a planar geometry, and the boron atom is considered to be sp 2 -hybridized. The electrons present in the outer shells continuously revolve around the nucleus in a spiral motion. An N-heterocyclic carbene boryl anion is an isoelectronic structure of an N -heterocyclic carbene (NHC), where the carbene carbon is replaced with a boron atom that has a -1 charge. ![]() bortezomib, crisaborole, and tavaborole) have been FDA approved and are in the clinic, and several other boron-containing compounds are in clinical trials. An atom consists of two parts a nucleus which lies at the centre and carries proton (positively charged particle) and neutron (negatively charged particle) and the other part is the outer shell that carries electrons (negatively charged particles). Boron is a trace element that is naturally present in many foods and available as a dietary supplement. Currently, a number of boron-based drugs (e.g. The incorporation of the "magic" boron atom has been established as an important new strategy in the field of medicinal chemistry as boron compounds have been shown to form various bonds with their biological targets. ![]()
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